Shop : Rezensionsexemplar
Shop
Rezensionsexemplar
Oktober 2024
In Vorbereitung
Philip von Platen
On Physiological Closed-Loop Control for Lung-Protective Mechanical Ventilation
Mechanical ventilation remains a cornerstone in the treatment of patients with respiratory failure. However, careful, constant, and lung-protective adjustment of ventilator settings is required to prevent ventilator-induced lung injury. This work presents contributions to the field of physiological closed-loop control, which has the potential to achieve continuous lung-protective mechanical ventilation and reduce clinician workload. First, the large signal behaviour of the respiratory system is studied, including the non-linear hysteretic phenomenon that significantly affects the operating points of tidal ventilation. A mathematical Preisach hysteresis model of the respiratory system is derived, accurately replicating clinically measured pressure-volume curves and serving as a foundation for the automation of lung recruitment manoeuvres. Next, the model-based design of robust closed-loop controllers for precise control of systemic oxygenation is described. Extensive simulations and results from animal experiments demonstrate the controllers' accuracy, reliability, and safety despite significant uncertainties in the process. Finally, a complete physiological closed-loop system capable of automatically adjusting all ventilator settings is presented. Results from animal trials demonstrate that the system can maintain subjects within defined targets while adhering to lung-protective guidelines and requiring minimal clinician interaction.
Schlagwörter: Mechanical Ventilation; Closed-Loop Control; Robust Control; Physiological Modelling; Hysteresis Modelling
Aachener Beiträge zur Medizintechnik
Herausgegeben von Univ.-Prof. Dr.-Ing. Dr. med. Steffen Leonhardt, Univ.-Prof. Dr.-Ing. Klaus Radermacher und Univ.-Prof. Dr. med. Dipl.-Ing. Thomas Schmitz-Rode, Aachen
Band 78
Shaker Verlag GmbHAm Langen Graben 15a52353 Düren
Mo. - Do. 8:00 Uhr bis 16:00 UhrFr. 8:00 Uhr bis 15:00 Uhr
Kontaktieren Sie uns. Wir helfen Ihnen gerne weiter.
